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Invariable z chains noncovalently linked to the TCR ab heterodimer 7. Three homologous CD3 chains, each covalently linked to the TCR ab heterodimer 6. The T cell receptor (TCR) complex contains: 3. T cells express CD4 or CD8 and do not recognize CD4 or CD8 on other cells.Ģ. Unlike the B cell receptor (immunoglobulins), the TCR can recognize only peptides displayed on MHC molecules, not soluble peptides alone. Although a small subset of T cells may recognize glycolipid antigens bound to class I MHC-like molecules called CD1, these T cells do not also recognize peptide antigens. As such, each ab T cell is restricted to bind either MHC class II or class I molecules, but not both. Mature ab T cells (the predominant type) express either CD4 or CD8, but not both.
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The receptor that recognizes peptide-MHC complexes is called the T cell receptor (TCR). MHC molecules and CD4 or CD8ĪNS: A Most T cells are specific for polymorphic residues of a self major histocompatibility complex (MHC) molecule, which accounts for their MHC restriction, and for residues of a peptide antigen displayed by the MHC molecule, which accounts for antigen Both soluble peptides and peptide-MHC complexes 6. Both MHC class I and class II molecules 4. A particular allelic form of a major histocompatibility complex (MHC) molecule and a peptide bound to the MHC molecule 3.
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Most T lymphocytes have a dual specificity for which one of the following pairs of molecules? 2. Test Bank for Basic Immunology Functions and Disorders of the Immune System 4th Edition by Abbas Chapter 04: Antigen Recognition in the Adaptive Immune System Test Bank MULTIPLE CHOICEġ.